Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI
نویسندگان
چکیده
منابع مشابه
Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties
The DAPI structure has been modified by replacing the phenyl group with substituted phenyl or heteroaryl rings. Twelve amidines were synthesized and their DNA binding, fluorescence properties, in vitro and in vivo activities were evaluated. These compounds are shown to bind in the DNA minor groove with high affinity, and exhibit superior in vitro antitrypanosomal activity to that of DAPI. Six n...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2016
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2016.11.006